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Updated: May 2, 2026
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Management of a patient with advanced BRAF-mutant melanoma
Michelle T Ashworth1, Adil Daud
1From Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.
Abstract:
A 49-year-old man initially diagnosed in 1995 with cutaneous melanoma presented to the authors' institution in 2009 with metastatic, BRAF V600E-mutant melanoma. His treatment course to date has included surgery, adjuvant radiotherapy, and interferon, metastasectomies, granulocyte-macrophage colony-stimulating factors, a clinical trial with the BRAF inhibitor vemurafenib (PLX-4032), clinical trial with combination BRAF plus MEK inhibition with vemurafenib plus GDC-0973, and combination targeted and immune therapy with vemurafenib plus the anti-CTLA4 antibody ipilimumab. This case report illustrates the long-term management of a patient with metastatic melanoma using targeted and immune therapy, evolution in treatment guidelines, next directions in research, and the critical role of clinical trials in advancement of patient care.
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