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Disorders of the Skeletal Muscle

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
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Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...

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Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
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Related Experiment Video

Updated: May 2, 2026

Manual Muscle Testing: A Method of Measuring Extremity Muscle Strength Applied to Critically Ill Patients

Manual Muscle Testing: A Method of Measuring Extremity Muscle Strength Applied to Critically Ill Patients

Published on: April 12, 2011

The patient with acute muscular weakness.

H Constable, F Wood, K Jones¹

¹Acute Medical Unit, Royal Bolton Hospital, Bolton.

|March 12, 2014

Summary

Early diagnosis of proximal muscle weakness is crucial for preventing severe complications like respiratory failure. Prompt assessment and investigation, including CK levels, guide timely treatment and identify potential rhabdomyolysis.

Area of Science:

Neurology
Internal Medicine
Emergency Medicine

Background:

Proximal muscle weakness presents acutely or subacutely to Acute Medical Units, necessitating urgent diagnosis.
Life-threatening complications include respiratory failure and cardiac disturbances, alongside significant disability.

Observation:

Diagnosis requires detailed history, physical examination to assess weakness onset, distribution, and severity.
Elevated creatine kinase (CK) levels suggest rhabdomyomyolysis.
Prompt respiratory function assessment is vital for patients with associated muscle weakness.

Findings:

Early diagnosis and treatment are essential to prevent severe outcomes.
High CK levels warrant suspicion for rhabdomyolysis.
Treatment should commence promptly, without awaiting definitive investigations.

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Implications:

Timely intervention can mitigate severe complications and disability.
A high CK level is a key indicator for rhabdomyolysis.
A poor response to treatment suggests an alternative diagnosis, requiring reassessment.