Related Experiment Video
Updated: May 2, 2026
05:23
Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
18.8K
Nocturnal enuresis in sickle cell disease
Rachel B Wolf1, Adetola A Kassim, Robert L Goodpaster
1Vanderbilt Medical Scholars Program, Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Expert Review of Hematology
|March 13, 2014
Summary
Nocturnal enuresis (bedwetting) affects 9% of young adults with sickle cell disease (SCD), impacting quality of life. This review explores causes and management strategies for SCD-related bedwetting.
Area of Science:
- Pediatrics
- Hematology
- Urology
Background:
- Nocturnal enuresis is a common issue in sickle cell disease (SCD) patients.
- Limited understanding exists regarding the causes and pathophysiology of enuresis in SCD.
- Approximately 9% of adults aged 18-20 with SCD experience nocturnal enuresis, affecting their quality of life.
Purpose of the Study:
- To review the natural history of nocturnal enuresis in individuals with SCD.
- To explore the postulated causes of enuresis in the context of SCD.
- To propose a rational approach for the evaluation and management of nocturnal enuresis in SCD.
Main Methods:
- Literature review focusing on nocturnal enuresis and sickle cell disease.
- Analysis of postulated etiologies including hyposthenuria, bladder dysfunction, arousal disorders, and sleep-disordered breathing.
- Synthesis of current knowledge to guide clinical practice.
Main Results:
- Nocturnal enuresis significantly impacts health-related quality of life, leading to reduced self-esteem and social isolation.
- Potential causes include nocturnal polyuria due to hyposthenuria, bladder issues, increased arousal thresholds, and sleep-disordered breathing.
- Currently, no evidence-based therapies are established for nocturnal enuresis in SCD.
Conclusions:
- Nocturnal enuresis is a significant concern for children and young adults with SCD.
- Further research is needed to elucidate the exact pathophysiology and develop effective treatments.
- A systematic evaluation and management approach is crucial for affected individuals.
More Related Videos
Related Concept Videos
01:22Diabetes Insipidus II: Pathophysiology
29
Normally, water balance is maintained through three interconnected mechanisms: the hypothalamic thirst center, the synthesis and release of antidiuretic hormone (ADH, or vasopressin), and the kidneys' responsiveness to this hormone. ADH is synthesized in the hypothalamus, released from the posterior pituitary, and acts on the distal nephron, allowing water reabsorption and concentrated urine production.Diabetes Insipidus and Its TypesIn diabetes insipidus (DI), this regulatory system is...
29
01:21Nursing Assessment of the Genitourinary System I: Health History
822
The genitourinary system is critical to maintaining fluid balance, waste elimination, and reproductive function. Nurses play a vital role in assessing this system, beginning with a thorough health history. This process involves gathering patient information, identifying risk factors, and recognizing symptoms of genitourinary disorders. Early detection is vital for timely interventions and management.1. Gathering Patient InformationA complete health history includes the patient’s personal,...
822
01:24Nephrotic Syndrome III : Nursing Management
549
Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
549
01:29Diabetes Insipidus I: Introduction
58
Definition Diabetes insipidus is a disorder marked by the production of large amounts of dilute urine because of impaired vasopressin production, release, or kidney response. The lack of effective vasopressin action limits water reabsorption in the renal collecting ducts, which leads to excessive urinary water loss and intense thirst.Clinical PresentationIndividuals with diabetes insipidus report persistent thirst and very high urine output. In severe cases, fluid intake can reach up to 20...
58
01:25Hemodialysis III: Nursing Management
1.8K
The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this...
1.8K
01:20Disorders of the Urinary System
2.2K
The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
2.2K