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Surface plasmon resonance for cell-based clinical diagnosis.
Yuhki Yanase1, Takaaki Hiragun2, Kaori Ishii3
1Department of Dermatology, Division of Molecular Medical Science, Graduate School of Biomedical Science, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8551, Japan. yyanase@hiroshima-u.ac.jp.
Sensors (Basel, Switzerland)
|March 13, 2014
Summary
Surface Plasmon Resonance (SPR) sensors offer label-free, real-time monitoring of living cells. This technology enables detailed observation of cellular functions and reactions, advancing life science research and clinical diagnostics.
Area of Science:
- Biotechnology
- Cell Biology
- Biosensing
Background:
- Growing demand for non-invasive, real-time methods to assess living cell conditions and functions in life sciences.
- Surface Plasmon Resonance (SPR) sensors provide label-free, real-time detection of refractive index changes on sensor chip surfaces.
Purpose of the Study:
- To highlight the utility of SPR sensors for evaluating living cell reactions to stimuli without labeling.
- To introduce the potential of Surface Plasmon Resonance Imaging (SPRI) for visualizing single-cell responses.
Main Methods:
- Utilizing Surface Plasmon Resonance (SPR) sensors for label-free, real-time monitoring of biological samples.
- Employing Surface Plasmon Resonance Imaging (SPRI) to visualize cellular behavior at the single-cell level.
Main Results:
- SPR sensors effectively evaluate living cells' real-time responses to various stimuli without requiring labels.
- SPRI systems demonstrate the capability to visualize individual cell reactions, offering high-resolution insights.
Conclusions:
- SPR and SPRI technologies are powerful tools for label-free, real-time cell analysis in life sciences.
- These techniques hold significant potential for advancing clinical diagnostics, including multi-array cell diagnostics and cancer cell detection.
