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Updated: May 2, 2026

Isolation and Culture Expansion of Tumor-specific Endothelial Cells
Published on: October 14, 2015
Endothelial cadherins in cancer
Georg Breier1, Marianne Grosser, Maryam Rezaei
1Institute of Pathology, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Germany, georg.breier@uniklinikum-dresden.de.
Cadherins are crucial for cell adhesion. In breast cancer, vascular endothelial cadherin (VE-cadherin) promotes tumor growth and invasion, highlighting its role in cancer progression alongside other cadherins.
Area of Science:
- Cell Biology
- Molecular Oncology
Background:
- Cadherins are cell adhesion receptors vital for tissue development and maintenance.
- Endothelial cells express vascular endothelial (VE)-cadherin at adherens junctions and neural (N)-cadherin externally.
- Altered cadherin expression, such as loss of epithelial (E)-cadherin or gain of N-cadherin, is linked to tumor progression.
Purpose of the Study:
- To investigate the role of VE-cadherin in breast carcinoma.
- To understand the interplay of cadherins in breast cancer progression.
Main Methods:
- The study focuses on analyzing cadherin expression patterns and their functional implications in breast cancer.
- Investigated the impact of VE-cadherin on tumor cell proliferation and invasion.
Main Results:
- Aberrant expression of VE-cadherin is observed in certain cancer types, including breast carcinoma.
- VE-cadherin promotes breast tumor cell proliferation and invasion by enhancing TGF-β signaling.
Conclusions:
- VE-cadherin is a significant factor in breast cancer progression.
- The 'cadherin switch' in breast cancer involves VE-cadherin in a complex interplay with other classical cadherins.
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