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Updated: May 2, 2026

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy
Published on: August 1, 2013
Tumor antigen-/cytokine-pulsed dendritic cells in therapy against lymphoma
Sumit K Hira1, Deepak Verma, Partha P Manna
1Immunobiology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, India.
Abstract:
Adoptive cell therapy using dendritic cells (DCs) is a strategy to deliver tumor antigens in cancer immunotherapy. Co-delivery of antigens to DC with essential components like genes encoding cytokines, chemokines, and other molecules or stimulation with recombinant cytokines is a potential method for designing an effective tumor vaccine protocol. Here, we describe the stimulation of purified splenic- or bone marrow-derived DC with recombinant interleukin-15 (IL-15) in the presence of intact soluble antigen from metastatic lymphoma tumor cells in an experimental animal model.
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