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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

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Triple-negative breast carcinoma: current and emerging concepts

Robert Schmadeka1, Bryan E Harmon, Meenakshi Singh

  • 1Stony Brook University School of Medicine, Health Sciences Tower, Level 4, Room 184, Stony Brook, NY 11794-8430; meenakshi.singh@stonybrookmedicine.edu.

American Journal of Clinical Pathology
|March 13, 2014
PubMed
Abstract

Insights

Triple-negative breast cancer (TNBC) is aggressive with limited targeted therapies. Research is advancing understanding of TNBC subtypes and biomarkers for new treatments.

Area of Science:

  • Oncology
  • Genomics
  • Molecular Biology

Background:

  • Triple-negative breast cancer (TNBC) is an aggressive cancer subtype.
  • TNBC disproportionately affects younger patients.
  • Effective targeted therapies for TNBC are currently limited.

Purpose of the Study:

  • To review current concepts in triple-negative breast carcinoma.
  • To discuss clinicopathologic features and histologic subtypes.
  • To explore molecular classification and biomarker potential.

Main Methods:

  • Review of existing literature on TNBC.
  • Analysis of histologic and molecular subtyping data.
  • Evaluation of biomarker prognostic and therapeutic potential.

Main Results:

  • Progress in subtyping TNBC tumors has been achieved.
  • Biomarkers have been discovered for targeted therapeutic efforts.
  • Novel targets are under exploration for TNBC treatment.

Conclusions:

  • Understanding TNBC clinicopathologic features is crucial.
  • Histologic and molecular subtypes impact prognosis and treatment.
  • Emerging targeted therapies show promise for TNBC management.
Keywords:
BiomarkersBreast cancerPathologyTherapeutic effortsTriple negative

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