Related Experiment Video
Updated: May 2, 2026
09:29
Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
Published on: March 20, 2020
19.8K
Triple-negative breast carcinoma: current and emerging concepts
Robert Schmadeka1, Bryan E Harmon, Meenakshi Singh
1Stony Brook University School of Medicine, Health Sciences Tower, Level 4, Room 184, Stony Brook, NY 11794-8430; meenakshi.singh@stonybrookmedicine.edu.
American Journal of Clinical Pathology
|March 13, 2014
Summary
Triple-negative breast cancer (TNBC) is aggressive with limited targeted therapies. Research is advancing understanding of TNBC subtypes and biomarkers for new treatments.
Area of Science:
- Oncology
- Genomics
- Molecular Biology
Background:
- Triple-negative breast cancer (TNBC) is an aggressive cancer subtype.
- TNBC disproportionately affects younger patients.
- Effective targeted therapies for TNBC are currently limited.
Purpose of the Study:
- To review current concepts in triple-negative breast carcinoma.
- To discuss clinicopathologic features and histologic subtypes.
- To explore molecular classification and biomarker potential.
Main Methods:
- Review of existing literature on TNBC.
- Analysis of histologic and molecular subtyping data.
- Evaluation of biomarker prognostic and therapeutic potential.
Main Results:
- Progress in subtyping TNBC tumors has been achieved.
- Biomarkers have been discovered for targeted therapeutic efforts.
- Novel targets are under exploration for TNBC treatment.
Conclusions:
- Understanding TNBC clinicopathologic features is crucial.
- Histologic and molecular subtypes impact prognosis and treatment.
- Emerging targeted therapies show promise for TNBC management.
Related Concept Videos
02:57Targeted Cancer Therapies
7.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.0K
01:33Cancer-Critical Genes I: Proto-oncogenes
9.1K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.1K
02:56Treatment Resistent Cancers
1.1K
1.1K
02:56Treatment Resistant Cancers
2.6K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
2.6K
02:30Metastasis
5.4K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.4K