Related Experiment Video
Updated: May 2, 2026

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System
Published on: October 20, 2023
Insomnia and hypnotic medications are associated with suicidal ideation in a community population
Wilfred R Pigeon1, Julie A Woosley, Kenneth L Lichstein
1a Center of Excellence for Suicide Prevention, VA Medical Center , Canandaigua , New York , USA.
Abstract:
Suicidal ideation (SI), a significant predictor of suicide, is associated with sleep disturbance, which is seldom assessed using stringent diagnostic criteria and validated sleep instruments in community samples. Cross-sectional data, including sleep diaries and validated instruments, from 767 community adults were used to identify variables associated with SI and subsequently entered into a regression model to predict SI. Suicidal ideation was endorsed by 9.3% of the sample. This group differed from non-ideators on several variables, but only insomnia diagnosis, depression severity, and hypnotic medication use predicted SI. Findings confirm an association of insomnia with SI using stringent criteria and controlling for depression. If treating insomnia is a conceivable pathway to reduce SI, the apparent risk posed by hypnotics may limit treatment options.
Related Concept Videos
Sedatives and Hypnotics Drugs: Miscellaneous Agents
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Management of Insomnia
Sedatives and Hypnotics: Overview
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
CNS Depressants: Barbiturates and Benzodiazepines
Sedatives and Hypnotics Drugs: Benzodiazepines
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...
Insomnia
Multiple factors contribute...

