Related Experiment Video
Updated: May 2, 2026

Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE
Published on: July 29, 2014
Mechanisms of RIG-I-like receptor activation and manipulation by viral pathogens
1Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.
Abstract:
RIG-I-like receptors (RLRs) play important roles in the host defense to numerous viral pathogens. Since they were discovered, much light has been shed on the molecular details of how these cytoplasmic viral RNA receptors sense viral infection and orchestrate antiviral innate immunity. Intriguingly, in addition to viral RNA binding, a series of posttranslational modifications (PTMs) is required for the rapid activation of RLRs and, inversely, for the prevention of aberrant innate immune signaling. Recent discoveries have shown that viruses manipulate the PTMs of RLRs to escape innate immune detection. This article highlights some of these recent findings in this fast-evolving field.
Related Concept Videos
Inhibitors of Viral Protein Synthesis
Intracellular Movement of Viruses and Bacteria
Viral Structure
Mechanisms of Retrovirus-induced Cancers
Immune Response Against Viral Pathogens
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Regulation of Bacterial Virulence

