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Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
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Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology

Published on: March 22, 2012

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Screening of the central nervous system in children with invasive pulmonary aspergillosis

Emmi Broenen1, Annelies Mavinkurve-Groothuis1, Karin Kamphuis-van Ulzen2

  • 1Department of Pediatrics, Radboud University Nijmegen Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

Medical Mycology Case Reports
|March 14, 2014
PubMed

Insights

Current guidelines for invasive pulmonary aspergillosis neglect screening for extra-pulmonary sites. Early detection of central nervous system (CNS) aspergillosis in children is crucial for effective antifungal treatment strategies.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Pediatric Medicine

Background:

  • Invasive pulmonary aspergillosis management guidelines often omit screening for extra-pulmonary infections.
  • Dissemination to the central nervous system (CNS) significantly impacts treatment choices and therapeutic drug monitoring for azole antifungals.

Purpose of the Study:

  • To highlight the necessity of screening pediatric patients for central nervous system (CNS) aspergillosis.
  • To advocate for a structured approach in evaluating CNS involvement in pediatric invasive aspergillosis.

Main Methods:

  • This study reviews existing literature and clinical guidelines.
  • It analyzes the implications of CNS aspergillosis on treatment decisions in pediatric populations.

Main Results:

  • Current guidelines do not recommend screening for extra-pulmonary sites, including the CNS.
  • Identifying CNS aspergillosis is critical for selecting appropriate antifungal agents and achieving target plasma concentrations.

Conclusions:

  • A structured screening protocol for CNS aspergillosis in pediatric patients is essential.
  • Adopting such an approach will improve patient outcomes by enabling timely and targeted antifungal therapy.
Keywords:
AspergillosisCentral nervous systemPediatricsScreeningTherapeutic drug monitoringVoriconazole

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