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Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
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Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology

Published on: March 22, 2012

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Invasive pulmonary aspergillosis post extracorporeal membrane oxygenation support and literature review

Benjamin J Parcell1, Pavan Kumar B C Raju2, Elizabeth M Johnson3

  • 1Department of Medical Microbiology, Ninewells Hospital and Medical School, Dundee, NHS Tayside, DD1 9SY Scotland, UK.

Medical Mycology Case Reports
|March 14, 2014
PubMed

Insights

Extracorporeal membrane oxygenation (ECMO) can lead to invasive pulmonary aspergillosis, a fungal infection. This case highlights successful treatment using antifungal drugs and interferon-gamma.

Area of Science:

  • Critical care medicine
  • Infectious diseases
  • Pulmonology

Background:

  • Extracorporeal membrane oxygenation (ECMO) use for reversible pulmonary failure has risen.
  • Nosocomial infections are significant complications during ECMO therapy.
  • Fungal infections are frequently implicated in ECMO-associated complications.

Purpose of the Study:

  • To report a case of invasive pulmonary aspergillosis in a patient undergoing ECMO.
  • To describe the successful treatment of this fungal infection.

Main Methods:

  • Case report of a critically ill patient on ECMO.
  • Diagnosis of invasive pulmonary aspergillosis.
  • Treatment with combination antifungal therapy and interferon-gamma.

Main Results:

  • Successful treatment of invasive pulmonary aspergillosis in an ECMO patient.
  • Demonstration of combination therapy efficacy.

Conclusions:

  • Invasive pulmonary aspergillosis is a potential complication of ECMO.
  • Combination antifungal therapy with interferon-gamma can be effective in treating this condition.
Keywords:
AnidulafunginAspergillus fumigatusExtracorporeal membrane oxygenation support

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