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Fungemia caused by Cyberlindnera fabianii: Clinical and microbiological insights from two fatal cases

Michał Sarzyński1, Maria Łuczak1, Adrian Bekier1,2

  • 1Department of Microbiology and Medical Laboratory Immunology, Medical University of Lodz, Łódź, 92-213, Poland.

Medical Mycology Case Reports
|August 1, 2026
PubMed

Insights

Two elderly patients with comorbidities died from invasive infections caused by the rare yeast Cyberlindnera fabianii. Antifungal susceptibility was variable, highlighting challenges in treating these opportunistic fungal infections.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Clinical Microbiology

Background:

  • Cyberlindnera fabianii is an opportunistic yeast causing invasive infections.
  • Invasive fungal infections pose significant challenges, especially in elderly patients with comorbidities.

Purpose of the Study:

  • To report two fatal cases of Cyberlindnera fabianii fungemia.
  • To analyze the antifungal susceptibility profile of C. fabianii.

Main Methods:

  • Case report of two elderly patients with C. fabianii fungemia.
  • Microbiological analysis including minimum inhibitory concentration (MIC) testing for antifungal agents.

Main Results:

  • Both patients were elderly with multiple comorbidities and experienced fatal outcomes.
  • C. fabianii showed low MICs to amphotericin B and echinocandins.
  • Fluconazole susceptibility was variable.

Conclusions:

  • Cyberlindnera fabianii can cause fatal invasive infections in vulnerable patients.
  • Antifungal treatment response was limited in one case.
  • Early identification and susceptibility testing are crucial for managing C. fabianii infections.
Keywords:
Antifungal susceptibilityCase reportCyberlindnera fabianii fungemiaOpportunistic yeast

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