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Emerging treatments for urinary incontinence.
Allison Polland1, Stephen Mock, Roger R Dmochowski
1The Mount Sinai Hospital, Department of Urology , 1 Gustave L. Levy Pl, Box 1272, New York, NY 10029 , USA.
Expert Opinion on Emerging Drugs
|March 15, 2014
Summary
Urinary incontinence (UI) management is evolving, with emerging therapies like cell therapy showing promise for stress UI. Current treatments for urge UI have comparable efficacy, and novel targets require further investigation.
Area of Science:
- Urology
- Gastroenterology
- Geriatrics
Background:
- Urinary incontinence (UI) significantly impacts patient quality of life and incurs substantial healthcare costs.
- The aging population and increased healthcare access contribute to rising expenditures for UI diagnosis and treatment.
Purpose of the Study:
- To provide an overview of UI and its burden.
- To review emerging therapies for UI management.
Main Methods:
- Literature review focusing on current and novel therapeutic targets for UI.
- Analysis of pharmacological and non-pharmacological treatment options.
Main Results:
- Pharmacological therapy for stress UI is limited; autologous muscle-derived cell therapy shows potential.
- Currently FDA-approved antimuscarinics for urge UI exhibit similar efficacy and adverse event profiles.
- Novel targets like transient receptor potential vanilloid type 1 and neurokinin-1 require additional research.
Conclusions:
- Antimuscarinics and beta-agonists are expected to remain primary treatments for urge UI.
- Autologous muscle-derived cell therapy represents a promising avenue for stress UI.
- Further investigation into novel therapeutic targets is crucial for advancing UI management.
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