Antitumor metastasis pregnane alkaloids from Pachysandra terminalis
Chuan Zhao1, Chun-Chun Gan, Mei-Na Jin
1a Research Center of Basic Medical Sciences, Tianjin Medical University , Tianjin 300070 , China.
Abstract:
Three new pregnane alkaloids, named terminamines H-J (1-3), together with two known alkaloids (4 and 5), were isolated from the ethanol extract of Pachysandra terminalis. The structures of isolated compounds were elucidated by spectroscopic methods, including (1)H and (13)C NMR, 2D NMR, and HR-ESI-MS. Compounds 1, 4, and 5 revealed significant anti-metastasis activities. In addition, compound 1 inhibited the expression of p-PKCζ in MDA-MB-231 cells, and compound 4 inhibited the expressions of p-PKCζ in MDA-MB-231 and A549 cells.
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