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Deep repetitive transcranial magnetic stimulation with H-coil on lower limb motor function in chronic stroke: a pilot
Raffaella Chieffo1, Serena De Prezzo1, Elise Houdayer1
1Scientific Institute Vita-Salute University San Raffaele, Neurological Department, Experimental Neurophysiology Unit, INSPE-Institute of Experimental Neurology, Milan, Italy.
Objectives:
To assess the efficacy of high-frequency (20 Hz) brain stimulation on lower limb motor function in subjects with chronic (> 6 mo) subcortical stroke.
Design:
Double-blind, placebo-controlled crossover study.
Setting:
University hospital.
Participants:
Right-handed subjects (N=10) affected by a first-ever subcortical stroke in the territory of the middle cerebral artery were included in this study.
Interventions:
Repetitive transcranial magnetic stimulation (rTMS) was delivered with the H-coil, specifically designed to target deeper and larger brains regions. Each subject received both real and sham rTMS in a random sequence. The 2 rTMS cycles (real or sham) were composed of 11 sessions each, administered over 3 weeks and separated by a 4-week washout period.
Main Outcome Measures:
Lower limb functions were assessed by the lower limb Fugl-Meyer scale, the 10-m walk test, and the 6-minute walk test before and 1 day after the end of each treatment period, as well as at a 4-week follow-up.
Results:
Real rTMS treatment was associated with a significant improvement in lower limb motor function. This effect persisted over time (follow-up) and was significantly greater than that observed with sham stimulation. A significant increase in walking speed was also found after real rTMS, but this effect did not reach statistical significance in comparison with the sham stimulation.
Conclusions:
These data demonstrated that 3 weeks of high-frequency deep rTMS could induce long-term improvements in lower limb functions in the chronic poststroke period, lasting at least 1 month after the end of the treatment.
