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Fungal toenail infections
1The University of East London, London, UK.
BMJ Clinical Evidence
|March 15, 2014
Summary
This systematic review evaluates oral and topical treatments for fungal toenail infections in adults. It found 13 studies on interventions like terbinafine and fluconazole, assessing their effectiveness and safety.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Fungal infections cause a significant portion of foot and nail conditions seen by dermatologists.
- Prevalence in the general population ranges from 3% to 12%.
Purpose of the Study:
- To systematically review the effects of oral and topical treatments for adult fungal toenail infections.
- To evaluate the effectiveness and safety of various antifungal interventions.
Main Methods:
- Systematic review of literature from Medline, Embase, and The Cochrane Library up to October 2013.
- Inclusion of 13 studies meeting predefined criteria.
- GRADE evaluation of evidence quality for interventions.
Main Results:
- The review identified and analyzed data from 13 relevant studies.
- Evidence quality for different interventions was assessed using the GRADE system.
Conclusions:
- Information on the effectiveness and safety of amorolfine, butenafine, ciclopirox, fluconazole, itraconazole, terbinafine, tioconazole, and topical ketoconazole is presented.
- This review provides a comprehensive overview of treatment options for fungal toenail infections.
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