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The Subjective Cognitive Decline Questionnaire (SCD-Q): a validation study.

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Summary
This summary is machine-generated.

The Subjective Cognitive Decline Questionnaire (SCD-Q) effectively quantifies self-perceived cognitive decline. Its informant-reported section (TheirCog) correlates with objective cognitive performance, aiding in impairment detection.

Keywords:
Alzheimer's diseasecognitiondiagnosismemorytest

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Area of Science:

  • Neuroscience
  • Psychometrics
  • Gerontology

Background:

  • Subjective cognitive decline (SCD) is increasingly recognized but lacks standardized quantification tools.
  • Accurate measurement of SCD is crucial for early detection and intervention in cognitive impairment.

Purpose of the Study:

  • To develop and validate the Subjective Cognitive Decline Questionnaire (SCD-Q) for quantifying SCD.
  • To assess the reliability and validity of the SCD-Q in diverse cognitive groups.

Main Methods:

  • The SCD-Q, comprising subject (MyCog) and informant (TheirCog) sections, was administered to 124 controls, 144 SCD individuals, 83 MCI subjects, and 46 AD patients.
  • The 24-item questionnaire assesses perceived decline in memory, language, and executive functions over two years.
  • Correlations with anxiety, depression, and neuropsychological tests were analyzed.

Main Results:

  • MyCog scores significantly differentiated controls from other groups (p < 0.05).
  • TheirCog scores showed significant differences across all groups, with a cut-off of 7/24 discriminating impairment (85% sensitivity, 80% specificity).
  • MyCog correlated with mood, while TheirCog correlated with neuropsychological tests; informant mood impacted TheirCog scores.

Conclusions:

  • The SCD-Q, particularly the MyCog component, effectively distinguishes SCD from controls.
  • The TheirCog component strongly relates to objective cognitive function and aids in identifying cognitive impairment.
  • The SCD-Q provides a comprehensive measure of self-perceived cognitive decline from both individual and informant perspectives.