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Updated: May 2, 2026

Design and Synthesis of a Reconfigurable DNA Accordion Rack
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Mechanically interlocked DNA nanostructures for functional devices.

Stefan-S Jester1, Michael Famulok

  • 1Kekulé-Institut für Organische Chemie und Biochemie and ‡LIMES Program Unit Chemical Biology & Medicinal Chemistry, c/o Kekulé Institut für Organische Chemie und Biochemie Universität Bonn , Gerhard-Domagk-Straße. 1, 53121 Bonn, Germany.

Accounts of Chemical Research
|March 18, 2014
PubMed
Summary
This summary is machine-generated.

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DNA origami technology enables the creation of functional DNA nanostructures with interlocked components for precise nanoscale motion. This advancement is crucial for developing sophisticated DNA-based nanomachines and nanorobotics.

Area of Science:

  • Nanotechnology
  • Supramolecular Chemistry
  • Biomolecular Engineering

Background:

  • DNA nanotechnology has matured, shifting towards functional architectures.
  • DNA origami technology allows precise 2D and 3D arrangement of DNA modules.
  • Interlocked DNA nanostructures are key for controlled nanoscale motion.

Purpose of the Study:

  • To review approaches for constructing interlocked DNA nanostructures.
  • To discuss progress, opportunities, and challenges in DNA-based rotaxanes and pseudorotaxanes.
  • To highlight the role of these architectures in future nanomachines.

Main Methods:

  • Utilizing DNA origami for precise orchestration of functional DNA architectures.
  • Designing and realizing interlocked DNA nanostructures, particularly double-stranded circular geometries.

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  • Employing various switching mechanisms (toehold, light, pcPNAs) for component control.

    • Main Results:

    • Demonstrated the potential of interlocked DNA architectures for nanomechanical components.
    • Illustrated the design and realization of elementary functional units for nanomachines.
    • Showcased progress in DNA-based rotaxanes and pseudorotaxanes.

    Conclusions:

    • Interlocked DNA nanostructures are vital for developing functional nanomachines and nanorobotics.
    • Switching methods are essential for reliable and controllable operation of DNA nanodevices.
    • Further research is needed to overcome challenges and advance DNA-based interlocked systems.