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Updated: May 2, 2026
Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
Published on: July 27, 2022
Study on clinical application of nano-hydroxyapatite bone in bone defect repair
Weimin Zhu1,2,3,4, Daping Wang1,2, Jianyi Xiong1,2
1a Department of Surgery , Guangzhou Medical University , Guangzhou , P. R. China.
Objective:
To study the clinical effect of bone defect treated with nano-hydroxyapatite(Nano-HA) artificial bone.
Methods:
From September 2009 to June 2012, 27 cases of bone defect were analyzed retrospectively. The position of bone defect included humerus, radius, ulna, femur, tibia and calcaneus. The range of bone defect was from 0.3 × 1.0 cm to 3 × 6.5 cm. Among them, there were 22 cases with fractures and 5 cases with tumors. All patients were treated with Nano-HA artificial bone. The ability of bone defect repair was evaluated by X-ray exams performed preoperatively and postoperatively. HSS scores were adopted for final evaluation at the latest follow-up.
Results:
The patients were followed up from 11 to 26 months (average of 18.5 months). No general side effects occurred. X-ray photo showed an integrity interface between Nano-HA and bone. Primary healing was obtained in all cases without any complication.
Conclusion:
The Nano-HA artificial bone had a good biocompatibility and could be an ideal artificial bone in the reconstruction of bone defect.
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