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Published on: August 9, 2024
[Facial angiofibromas associated to tuberous sclerosis treated with topical sirolimus]
Mathias Tiedemann Svendsen1, Anette Bygum, Lars Kjærsgaard Hansen
1Hudafdeling I og Allergicenter, Odense Universitetshospital, Sdr. Boulevard 29, 5000 Odense C. m_tiedemann@hotmail.com.
Abstract:
We present a five-year-old boy with facial angiofibromas associated to tuberous sclerosis successfully treated with topical sirolimus 0.4% applied three times a week for six months. After six months we observed a nearly complete resolution of facial angiofibromas. The blood levels of sirolimus remained under a detectable limit and no side-effects were observed. Topically applied sirolimus seems to be a safe and effective alternative to surgery or laser therapy.

