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Updated: May 2, 2026
A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
Published on: May 3, 2021
[Osteosarcoma and ATR-16 syndrome: association or coincidence?]
A Regueiro García1, R Saborido Fiaño1, L González Calvete1
1Servicio de Hematología y Oncología Pediátrica, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, España.
Abstract:
ATR-16 syndrome is due to alterations on chromosome 16p13.3, and is usually accompanied by alpha-thalassemia, mild-moderate mental retardation, dysmorphic facial features, skeletal and genitourinary malformations. There are no references of the combination of ATR-16 syndrome and osteosarcoma in the literature. Osteosarcoma usually has a complex karyotype, characterized by a high degree of heterogeneity of chromosomal aberrations, among which is the involvement of chromosome 16. We report a case of a patient with ATR-16 syndrome diagnosed with femoral osteosarcoma.
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