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Related Concept Videos

Chromatin Structure Regulates pre-mRNA Processing02:41

Chromatin Structure Regulates pre-mRNA Processing

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In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
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Chromatin Structure and RNA Splicing02:41

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Pre-mRNA Processing: Modification of pre-mRNA Ends01:35

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In eukaryotic cells, transcripts made by RNA polymerase are modified and processed before exiting the nucleus. Unprocessed RNA is called precursor mRNA or pre-mRNA to distinguish it from mature mRNA.
Once about 20-40 ribonucleotides have been joined together by RNA polymerase, a group of enzymes adds a cap to the 5' end of the growing transcript. In this process, a 5' phosphate is replaced by modified guanosine that has a methyl group attached (7-methyl guanosine). This 5' cap helps...
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Types of RNA01:20

Types of RNA

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Types of RNA01:23

Types of RNA

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
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pre-mRNA Processing02:01

pre-mRNA Processing

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In eukaryotic cells, transcripts made by RNA polymerase are modified and processed before exiting the nucleus. Unprocessed RNA is called precursor mRNA or pre-mRNA to distinguish it from mature mRNA.
Once about 20-40 ribonucleotides have been joined together by RNA polymerase, a group of enzymes adds a “cap” to the 5’ end of the growing transcript. In this process, a 5’ phosphate is replaced by modified guanosine that has a methyl group attached to it (7-Methyl...
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RNA-Associated Chromatin DNA-DNA Interaction Method
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RNA-Associated Chromatin DNA-DNA Interaction Method

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Interplay between chromatin and RNA processing.

Olivier Mathieu1, Nicolas Bouché2

  • 1Clermont Université, Université Blaise Pascal, GReD, BP 10448, F-63000 Clermont-Ferrand, France; CNRS, UMR 6293, GReD, F-63001 Clermont-Ferrand, France; INSERM, UMR 1103, GReD, F-63001 Clermont-Ferrand, France.

Current Opinion in Plant Biology
|March 18, 2014
PubMed
Summary
This summary is machine-generated.

Chromatin context influences RNA processing, including polyadenylation site selection. Epigenetic marks in gene introns affect transcription, while RNA processing factors regulate chromatin.

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Chromatin Isolation by RNA Purification ChIRP
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Chromatin Isolation by RNA Purification ChIRP
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Area of Science:

  • Molecular Biology
  • Epigenetics
  • Plant Science

Background:

  • Chromatin structure plays a crucial role in gene regulation.
  • RNA processing events, such as polyadenylation site selection, are critical for gene expression.
  • The interplay between chromatin and RNA processing is an emerging area of research.

Purpose of the Study:

  • To review recent studies on the interplay between chromatin state and RNA processing in Arabidopsis thaliana.
  • To highlight the reciprocal relationship between chromatin modifications and RNA processing machinery.
  • To discuss the role of epigenetic marks in influencing transcription and RNA processing.

Main Methods:

  • Review of recent studies in Arabidopsis thaliana.
  • Analysis of findings on epigenetic marks and their associated factors.
  • Examination of the roles of splicing and polyadenylation factors in chromatin regulation.

Main Results:

  • Heterochromatin marks within gene introns can influence transcription.
  • Novel factors binding to epigenetic marks regulate polyadenylation site choice and mRNA processing.
  • Proteins involved in splicing and polyadenylation can also regulate DNA methylation and chromatin silencing.

Conclusions:

  • A complex and reciprocal relationship exists between chromatin state and RNA processing in plants.
  • Epigenetic modifications and RNA processing machineries are interconnected regulatory systems.
  • Understanding this interplay is key to comprehending gene expression control in Arabidopsis.