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Updated: May 2, 2026
Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
Published on: December 16, 2013
Characterization and biological activities of two copper(II) complexes with dipropylenetriamine and diamine as
Mousa AL-Noaimi1, Mohammad I Choudhary2, Firas F Awwadi3
1Department of Chemistry, Hashemite University, P.O. Box 150459, Zarqa 13115, Jordan.
Abstract:
Two new mixed-ligand copper(II) complexes, [Cu(dipn)(NN)]Br2(1-2) [dipn=dipropylenetriamine, NN=ethylenediamine (en) (1) and propylenediamine (pn) (2)], have been synthesized. These complexes were characterized by spectroscopic and thermal techniques. Crystal structure for 2 shows a distorted trigonal-bipyramidal geometry around Cu(II) ion with one solvate water molecule. Antimicrobial and antiproliferative assays were conducted to evaluate the biological activities of these complexes. The complexes exhibit a promising antimicrobial effect against an array of microbes at 200μg/mL concentration. The antiproliferative assay shows a high potential of these complexes to target Human keratinocyte cell line with IC50 values of 155 and 152μM. The absorption spectrum of 2 in water was modeled by time-dependent density functional theory (TD-DFT).
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