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Quantification of the Respiratory Burst Response as an Indicator of Innate Immune Health in Zebrafish
Published on: September 12, 2013
Innate immunity in disease
David E Elliott1, Sana S Siddique2, Joel V Weinstock2
1Division of Gastroenterology/Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, Iowa.
Abstract:
Cells can innately recognize generic products of viruses, bacteria, fungi, or injured tissue by engagement of pattern recognition receptors. Innate immune cells rapidly respond to this engagement to control commensals, thwart pathogens, and/or prompt repair. Insufficient or excessive activation of the innate immune response results in disease. This review focuses on pattern recognition receptors and cells of the innate immune system that are important for intestinal function. Our improving knowledge pertaining to this important aspect of our immune response is opening potential important new therapeutic opportunities for the treatment of disease.
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