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Chimeric fusion karyotypes in childhood B-cell acute lymphoblastic leukemia
Lily S Kerketta1, Vundinti Babu Rao, Kanjaksha Ghosh
1Department of Cytogenetics, National Institute of Immunohematology, KEM Hoapital, Parel, Mumbai, India. kanjakshaghosh@hotmail.com.
Indian Pediatrics
|March 18, 2014
Abstract:
Cytogenetics study using combination of conventional cytogenetics and fluorescent insitu hybridization was carried out in 171 pediatric acute lymphoblastic leukemia patients subgrouped to B-ALL (n=126) and T-ALL (n=45) by bone marrow morphology and immunophenotype. The chromosomal aberration frequency in B-ALL and T-ALL was 79% and 71%, respectively. TEL/AML1 translocation was detected in 28% of patients.
