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Amyloid-hydroxyapatite bone biomimetic composites.

Chaoxu Li1, Anne-Kathrin Born, Thomas Schweizer

  • 1ETH Zurich, Food & Soft Materials, Department of Health Science & Technology, Schmelzbergstrasse 9, LFO, E23, 8092, Zürich, Switzerland.

Advanced Materials (Deerfield Beach, Fla.)
|March 18, 2014
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Summary
This summary is machine-generated.

Researchers created novel bone-like nanocomposites using hydroxyapatite and amyloid fibrils. These materials mimic cancellous bone

Keywords:
amyloid fibrilsbiomimetic materialsbone-mimetic nanocompositeshydroxyapatiteosteoblast

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Tissue Engineering

Background:

  • Natural bone possesses a complex hierarchical structure.
  • Developing synthetic materials that mimic bone properties is crucial for regenerative medicine.
  • Hydroxyapatite and amyloid fibrils are promising biomaterials.

Purpose of the Study:

  • To develop a "bottom up" synthesis strategy for high aspect ratio hydroxyapatite (and brushite) platelets.
  • To combine these platelets with amyloid fibrils to create layered hybrid nanocomposites.
  • To evaluate the physical and biological properties of the resulting nanocomposites.

Main Methods:

  • A "bottom up" approach was used to synthesize hydroxyapatite and brushite platelets.
  • Layered hybrid nanocomposites were formed by combining the platelets with amyloid fibrils.
  • Density and elastic modulus of the nanocomposites were measured.
  • Cell adhesion and spreading of human trabecular bone-derived pre-osteoblasts were assessed.

Main Results:

  • High aspect ratio hydroxyapatite and brushite platelets were successfully synthesized.
  • Layered hybrid nanocomposites were fabricated by combining platelets with amyloid fibrils.
  • The nanocomposites exhibited a hierarchical structure.
  • The density and elastic modulus of the nanocomposites matched those of cancellous bone.
  • Good adhesion and spreading of pre-osteoblasts cells were observed on the nanocomposites.

Conclusions:

  • A novel "bottom up" strategy enables the synthesis of hydroxyapatite/amyloid fibril nanocomposites.
  • These nanocomposites possess bone-like physical properties (density, elastic modulus).
  • The developed materials show promise for bone tissue engineering applications due to good cell compatibility.