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A surface-modified poly(ɛ-caprolactone) scaffold comprising variable nanosized surface-roughness using a plasma

HoJun Jeon1, Hyeongjin Lee, GeunHyung Kim

  • 1Department of Bio-Mechatronic Engineering, College of Biotechnology and Bioengineering, Sungkyunkwan University , Suwon, South Korea .

Tissue Engineering. Part C, Methods
|March 19, 2014
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Summary

This study developed a novel, hydrophilic poly (ɛ-caprolactone) scaffold using advanced plasma treatment. Optimized nanoscale surface roughness significantly enhanced osteoblast-like cell responses for tissue engineering applications.

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Surface Science

Background:

  • Poly (ɛ-caprolactone) (PCL) is widely used in tissue regeneration but its hydrophobicity limits applications.
  • Developing hydrophilic PCL scaffolds is crucial for broader tissue engineering use.

Purpose of the Study:

  • To create a porous, multilayered PCL scaffold with enhanced hydrophilic properties and nanoscale surface roughness.
  • To investigate the impact of a novel oxygen plasma treatment on PCL scaffold surface characteristics and cellular responses.

Main Methods:

  • Fabrication of porous, multilayered PCL scaffolds using melt-plotting.
  • Application of an innovative oxygen plasma treatment to induce nanoscale surface roughness.
  • Culturing osteoblast-like cells on untreated, conventionally plasma-treated, and innovatively plasma-treated PCL scaffolds.
  • Assessment of cell viability, morphology, ALP activity, and calcium mineralization.

Main Results:

  • The novel plasma treatment created scaffolds with outstanding hydrophilic properties and homogeneously distributed nanosized pits.
  • An optimized nanoscale roughness (654 ± 91 nm) significantly improved cell viability, proliferation, and differentiation compared to untreated and conventionally treated scaffolds.
  • Enhanced ALP activity and calcium mineralization were observed on scaffolds with optimized nanoscale roughness.

Conclusions:

  • Innovative oxygen plasma treatment effectively enhances PCL scaffold hydrophilicity and surface topography.
  • Tailored nanoscale surface roughness is critical for promoting favorable cellular responses in PCL-based tissue engineering.
  • This approach offers a promising strategy for developing advanced PCL scaffolds for regenerative medicine.