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[Alpha fetoprotein in maternal serum in pregnancies with trisomy 18]
1Institut für Humangenetik, Klinikum der J.W. Goethe-Universität, Frankfurt.
Zeitschrift Fur Geburtshilfe Und Perinatologie
|September 1, 1988
Abstract:
Maternal serum alpha-fetoprotein (MS-AFP) was assayed before amniocentesis in 2441 pregnancies of women age 35 or over and of women with prior birth of a child with a chromosome anomaly. Ten cases of trisomy 18 and 25 cases of trisomy 21 were detected. In trisomy 18 without neural tube defect we found MS-AFP levels significantly lower than in trisomy 21.