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Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
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Altered lung development in bronchopulmonary dysplasia

Alice Hadchouel1, Marie-Laure Franco-Montoya, Christophe Delacourt

  • 1INSERM, U955, IMRB, Equipe 04, Créteil, France; AP-HP, Hôpital Necker-Enfants Malades, service de Pneumologie Pédiatrique, Centre de Référence pour les Maladies Respiratoires Rares de l'Enfant, Paris, France; Université Paris-Descartes, Paris, France.

Birth Defects Research. Part A, Clinical and Molecular Teratology
|March 19, 2014
PubMed

Insights

Bronchopulmonary dysplasia (BPD) is a complex lung disease in premature infants. This review explores the molecular pathways and genetic factors contributing to impaired alveolar growth in BPD.

Area of Science:

  • Neonatology
  • Pulmonary Medicine
  • Genetics

Background:

  • Bronchopulmonary dysplasia (BPD) is the primary respiratory complication in extremely premature infants.
  • Its complex pathophysiology involves host-environment interactions and genetic influences.
  • BPD's clinical and histological features have evolved with improved neonatal care and the management of more immature infants.

Purpose of the Study:

  • To review the key molecular pathways involved in the development of Bronchopulmonary dysplasia (BPD).
  • To highlight the role of genetic factors and evolving understanding of BPD pathogenesis.
  • To discuss insights gained from animal models, genetic studies, and functional respiratory assessments.

Main Methods:

  • Literature review focusing on molecular pathways in BPD.
  • Analysis of genetic approaches and their contribution to understanding BPD.
  • Inclusion of data from animal models and long-term respiratory functional studies.

Main Results:

  • Impaired alveolar growth is a consistent and key feature of BPD, particularly in newer forms.
  • Molecular pathways are increasingly identified as crucial in BPD genesis.
  • Genetic factors significantly influence the complex pathophysiology of BPD.

Conclusions:

  • Understanding the molecular basis of BPD is critical for developing targeted therapies.
  • Genetic predisposition plays a significant role in BPD development.
  • Continued research integrating molecular, genetic, and functional data is essential for advancing BPD care.

Keywords:
VEGFairwayalveolarizationgeneticslung functionmetalloproteinasespreterm

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