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Updated: May 2, 2026

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

[In vitro study on injectable alginate-strontium hydrogel for bone tissue engineering].

Yiji Tu, Tianlong Wu, Aifang Ye

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi = Zhongguo Xiufu Chongjian Waike Zazhi = Chinese Journal of Reparative and Reconstructive Surgery

|March 20, 2014

Summary

Alginate-strontium (Sr) hydrogel shows promise as an injectable bone tissue engineering scaffold. This material effectively promotes bone marrow mesenchymal stem cell (BMSC) proliferation and osteogenic differentiation, indicating its potential for bone regeneration applications.

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Last Updated: May 2, 2026

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

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Published on: October 26, 2016

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Published on: August 7, 2016

Bioprintable Alginate/Gelatin Hydrogel 3D In Vitro Model Systems Induce Cell Spheroid Formation

Bioprintable Alginate/Gelatin Hydrogel 3D In Vitro Model Systems Induce Cell Spheroid Formation

Published on: July 2, 2018

Area of Science:

Biomaterials Science
Tissue Engineering
Regenerative Medicine

Background:

Injectable scaffolds are crucial for bone tissue engineering, requiring materials with suitable physicochemical properties and biocompatibility.
Alginate hydrogels are widely explored, but incorporating strontium (Sr) may enhance their osteogenic potential.

Purpose of the Study:

To evaluate the potential of alginate-strontium (Sr) hydrogel as an injectable scaffold for bone tissue engineering.
To compare the properties and biological performance of alginate-Sr hydrogel against alginate-calcium (Ca) hydrogel.

Main Methods:

Fabrication of alginate-Sr and alginate-Ca hydrogel beads.
Characterization of hydrogel microstructure, mechanical properties, swelling, and degradation.
Assessment of bone marrow mesenchymal stem cell (BMSC) viability, proliferation, and osteogenic differentiation (ALP activity, gene expression, calcium deposition).

Main Results:

Alginate-Sr hydrogel exhibited a higher compression modulus than alginate-Ca hydrogel, with similar swelling rates and good degradability.
Significantly enhanced BMSC proliferation was observed in alginate-Sr hydrogel compared to alginate-Ca hydrogel.
Alginate-Sr hydrogel significantly promoted osteogenic differentiation, evidenced by increased ALP activity, osteogenic gene expression (OSX, Collagen I, Runx2), and calcium deposition.

Conclusions:

Alginate-Sr hydrogel possesses favorable physicochemical properties for bone tissue engineering.
The material effectively supports BMSC proliferation and osteogenic differentiation.
Alginate-Sr hydrogel is identified as an excellent injectable scaffold material for bone regeneration.