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Cyclooxygenase-2 inhibitor celecoxib suppresses invasion and migration of nasopharyngeal carcinoma cell lines through

Wen-Wen Li, Guo-Xian Long, Dong-Bo Liu

    Die Pharmazie
    |March 20, 2014
    PubMed

    Insights

    Celecoxib, a COX-2 inhibitor, effectively suppresses nasopharyngeal carcinoma cell invasion and migration. This anti-metastatic effect is linked to the inhibition of matrix metalloproteinase-2 and -9 (MMP-2/9) activity.

    Area of Science:

    • Oncology
    • Pharmacology

    Background:

    • The role of celecoxib, a selective COX-2 inhibitor, in human tumor development is well-documented.
    • Its anti-metastatic potential in nasopharyngeal carcinoma (NPC) remains largely unexplored.

    Purpose of the Study:

    • To investigate the anti-metastatic effects of celecoxib on NPC cell lines in vitro.
    • To elucidate the underlying mechanisms, particularly focusing on matrix metalloproteinase (MMP) activity.

    Main Methods:

    • Human NPC cell lines (HNE1, HONE1, SUNE1-5-8F) were treated with varying concentrations of celecoxib.
    • MTT assays assessed anti-proliferation effects.
    • Transwell and wound healing assays evaluated invasion and migration.
    • Gelatin zymography measured MMP-2 and MMP-9 activity.

    Main Results:

    • Celecoxib demonstrated significant inhibition of NPC cell proliferation.
    • Cellular invasion and migration capabilities were markedly suppressed by celecoxib treatment.
    • A dose-dependent inhibition of MMP-2 and MMP-9 activity was observed in all tested NPC cell lines.

    Conclusions:

    • Celecoxib exhibits anti-metastatic properties against nasopharyngeal carcinoma cells in vitro.
    • The suppression of MMP-2 and MMP-9 activity is a key mechanism contributing to celecoxib's anti-invasive and anti-migratory effects in NPC.

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