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Updated: May 2, 2026

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
Host-directed therapy of tuberculosis: what is in it for microRNA?
Marco Iannaccone1, Anca Dorhoi, Stefan H E Kaufmann
1Max Planck Institute for Infection Biology, Department of Immunology , Charitéplatz 1, D-10117, Berlin , Germany +49 30 28460 500 ; +49 30 28460 501 ; kaufmann@mpiib-berlin.mpg.de.
Abstract:
Tuberculosis (TB) is a major health threat and current intervention measures are far from satisfactory. MicroRNAs (miRs) have become major targets of investigations for different diseases due to their propensity to regulate gene expression in various biological processes. More recently, miRs have been found to play key roles in the control of infectious diseases. Consequently, the potential of miRs for diagnosis and therapy of TB is being considered. In this editorial, we discuss most recent lines of evidence for regulation of the immune response in TB by miRs that could form the basis for diagnosis and host-directed therapy in adjunct to canonical intervention measures in TB.
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