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Updated: May 2, 2026
A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Diterpenes inhibiting NO production from Euphorbia helioscopia
Hongqiang Chen1, Hao Wang2, Bo Yang3
1College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China; College of Pharmacy, Harbin University of Commerce, Harbin 150076, China.
Abstract:
Three new jatrophane diterpenes (1-3), an unreported spectroscopic data jatrophane diterpenene (4), and nine known analogues (5-13) have been isolated from the whole plants of Euphorbia helioscopia. Their structures were established by detailed spectroscopic data analyses (IR, ESIMS, HR-ESIMS, and 1D and 2D NMR), and the structure of 1 was confirmed by X-ray crystallography. The diterpenes showed inhibitory activities on LPS-induced NO production in murine microglial BV-2 cells.
