Related Experiment Video
Updated: May 2, 2026
04:44
Inter-Brain Synchrony in Open-Ended Collaborative Learning: An fNIRS-Hyperscanning Study
Published on: July 21, 2021
4.2K
KIBRA: In the brain and beyond
Lin Zhang1, Shuping Yang1, Dirk Oliver Wennmann2
1Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Cellular Signalling
|March 20, 2014
Summary
KIBRA influences memory and cognition in mammals. This protein also regulates the Hippo pathway, impacting cell processes like growth and migration, and is crucial in brain function.
Area of Science:
- Neuroscience
- Molecular Biology
- Cell Biology
Background:
- The KIBRA gene is linked to memory and cognitive performance in mammals through genetic studies.
- KIBRA is identified as a regulator of the Hippo signaling pathway, vital in tumorigenesis.
- KIBRA participates in diverse cellular functions, including polarity, trafficking, mitosis, and migration.
Purpose of the Study:
- To review and discuss recent advancements in understanding KIBRA's function.
- To explore the regulation of KIBRA in both neural and non-neural contexts.
- To highlight KIBRA's multifaceted roles in physiology.
Main Methods:
- Genome-wide single nucleotide polymorphism screening in mammals.
- Genetic studies in Drosophila and human cell lines.
- Biochemical analysis of KIBRA protein phosphorylation.
Main Results:
- KIBRA's association with memory and cognition is established.
- KIBRA's role as a novel regulator of the Hippo pathway is confirmed.
- KIBRA's involvement in cell polarity, trafficking, mitosis, and migration is indicated.
Conclusions:
- KIBRA is a key protein with significant roles in the brain and other tissues.
- Understanding KIBRA's regulation and function is critical for various physiological processes.
- Further research into KIBRA's mechanisms can inform therapeutic strategies for cognitive disorders and cancer.
Related Concept Videos
01:30Organization of the Brain
3.8K
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
3.8K
01:15Functional Brain Systems: Limbic System
8.8K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
8.8K
01:28Traumatic Brain Injury l: Introduction
25
DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...
25
01:22Neurons as Communicators of the Brain
5.2K
Neurons, the fundamental units of the brain and nervous system, function as the primary transmitters of information throughout the body. Their ability to communicate through electrical and chemical signals is vital for every bodily function, from regulating the heartbeat to processing complex thoughts. Each neuron has three main components: the cell body (soma), dendrites, and an axon, each specialized to facilitate swift and efficient neural communication.
Cell Body
The cell body, also known...
Cell Body
The cell body, also known...
5.2K
01:22Gut-Brain Axis
222
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such...
222
00:49The Blood-brain Barrier
47.3K
Overview
47.3K