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High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
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[Not Available].

T Löscher1, M Hoelscher

  • 1Klinikum der Ludwig-Maximilians-Universität, München, DE.

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Traveler's diarrhea, a common foodborne illness, stems from diverse causes like bacteria and viruses. Diagnosis and treatment strategies, including antibiotics and new vaccines, are evolving for better patient outcomes.

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Area of Science:

  • Infectious Diseases
  • Travel Medicine
  • Microbiology

Context:

  • Foodborne infections are a primary health concern for travelers, particularly in regions with substandard hygiene.
  • Traveler's diarrhea is the most frequent manifestation, but severe or chronic conditions like shigellosis and hepatitis A can also occur.

Purpose:

  • To review the heterogeneous etiology of traveler's diarrhea, including common bacterial and viral pathogens.
  • To discuss advancements in diagnostic methods such as PCR and ELISA for improved sensitivity.
  • To outline current and developing therapeutic and prophylactic strategies, including antibiotics and vaccines.

Summary:

  • Enterotoxigenic Escherichia coli (ETEC), Salmonella, Shigella, Campylobacter, and rotavirus are leading causes of traveler's diarrhea.
  • Modern diagnostics enhance detection, but a stepwise approach is recommended due to cost and clinical utility.
  • Antibiotics like ciprofloxacin are useful, but their empirical use should be judicious, reserved for severe cases.

Impact:

  • Improved diagnostic accuracy and targeted treatment can reduce the burden of traveler's diarrhea.
  • Development of new vaccines and antisecretory drugs promises enhanced prevention and management strategies.
  • Restricting empirical antibiotic use can mitigate antimicrobial resistance, preserving treatment efficacy.