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Updated: May 2, 2026

Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
Published on: December 15, 2017
Selective homocysteine turn-on fluorescent probes and their bioimaging applications
Hye Yeon Lee1, Yoon Pyo Choi, Sunkyung Kim
1Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, Korea. jyoon@ewha.ac.kr.
Abstract:
The design and development of new pyrene-based fluorescent probes, P-Hcy-1 and P-Hcy-2, which display selective fluorescence enhancements in response to homocysteine (Hcy), are described. The distinctly different fluorescence responses of P-Hcy-1 and P-Hcy-2 to Hcy vs. Cys are explained by theoretical calculations. Finally, the results of cell experiments show that these probes can be used to selectively detect Hcy in mammalian cells.
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