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Embryonic Connective Tissues

Embryonic Connective Tissues

During early development, the embryo forms two types of connective tissues— the mesenchyme and mucoid connective tissue.
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development.

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Related Experiment Video

Updated: May 2, 2026

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Published on: April 12, 2021

Tissue crosstalk in lung development.

Elizabeth A Hines¹, Xin Sun

¹Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin, 53706.

Journal of Cellular Biochemistry

|March 20, 2014

Summary

This summary is machine-generated.

This review explores lung development, focusing on tissue interactions and molecular crosstalk essential for normal lung formation and repair. Understanding these processes is key to addressing pulmonary diseases like bronchopulmonary dysplasia.

Keywords:

AIRWAYS DEVELOPMENTAL SIGNALING EPITHELIUM MESENCHYME TRACHEA

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Published on: April 12, 2021

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Mouse Embryonic Lung Culture, A System to Evaluate the Molecular Mechanisms of Branching

Mouse Embryonic Lung Culture, A System to Evaluate the Molecular Mechanisms of Branching

Published on: June 30, 2010

Area of Science:

Developmental biology
Pulmonology
Cell biology

Background:

Lung development is a complex process involving epithelial-mesenchymal tissue interactions.
Disruptions in lung development can lead to serious pulmonary diseases such as bronchopulmonary dysplasia and pulmonary hypertension.
Understanding the molecular mechanisms of these interactions is crucial for therapeutic interventions.

Purpose of the Study:

To review current evidence on tissue interactions and molecular crosstalk in lung development.
To highlight key signaling pathways involved in lung patterning and repair.
To identify knowledge gaps, particularly in understanding upper airway cartilage and smooth muscle interactions.

Main Methods:

Review of existing literature on lung development.
Analysis of studies using genetically engineered mouse models.
Inclusion of data from lung organ culture and advanced imaging techniques.

Main Results:

Established roles of FGF, BMP, WNT, and SHH in epithelial-mesenchymal crosstalk for lung specification and branching.
VEGF's role in epithelial-endothelial crosstalk coordinating airway branching and angiogenesis.
Recent discovery of SHH's involvement in mesothelium epithelial-to-mesenchymal transition (EMT).

Conclusions:

Tissue interactions and molecular crosstalk are fundamental to stereotypic lung patterning.
These interactions are critical for both normal lung development and injury repair mechanisms.
Further research is needed to elucidate the molecular basis of interactions in specific lung structures, like upper airway cartilage and smooth muscle.