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Alterations in Muscle Tone lll01:11

Alterations in Muscle Tone lll

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Related Experiment Video

Updated: May 2, 2026

Quantifying Arms and Legs Contributions during Repetitive Electrically-Assisted Sit-To-Stand Exercise in Paraplegics: A Pilot Study
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[Stiff person syndrome--case report].

Kazimierz Tomczykiewicz, Zanna Pastuszak, Jacek Staszewski

    Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
    |March 21, 2014
    PubMed
    Summary
    This summary is machine-generated.

    Stiff person syndrome (SPS) is a rare neurological disorder causing muscle stiffness and spasms. This case highlights an atypical SPS presentation with high anti-GAD antibodies and positive electrophysiological findings, successfully treated with diazepam.

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    Area of Science:

    • Neurology
    • Immunology

    Background:

    • Stiff person syndrome (SPS) is a rare autoimmune neurological disorder characterized by progressive muscle rigidity and spasms.
    • It is often associated with type 1 diabetes and paraneoplastic syndromes, frequently linked to high titers of anti-glutamic acid decarboxylase (GAD) antibodies.

    Observation:

    • This report details a patient presenting with an atypical course of Stiff person syndrome.
    • Diagnostic confirmation involved identifying high anti-GAD antibody levels and observing involuntary motor unit potential discharge in paraspinal muscles at rest.

    Findings:

    • The patient exhibited characteristic electrophysiological findings of involuntary motor unit discharge and co-contraction of agonist and antagonist muscles.
    • High serum anti-GAD antibody titers were confirmed, supporting the diagnosis of Stiff person syndrome.

    Implications:

    • This case underscores the diagnostic challenges in Stiff person syndrome, particularly with atypical presentations.
    • Effective management with diazepam was observed, suggesting its continued utility in treating SPS symptoms.