Related Experiment Video
Updated: Feb 21, 2026
09:02
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
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Contrast-Associated Acute Kidney Injury After Thrombectomy for Ischemic Stroke: Prognostic Impact and CAN-REST
Ghil Schwarz1,2, Angelo Cascio Rizzo2, Gareth Ambler3
1Stroke Center, Service of Neurology, Department of Clinical Neurosciences, University Hospital of Lausanne and University of Lausanne, Switzerland.
Neurology
|February 19, 2026
Summary
Contrast-associated acute kidney injury (CA-AKI) affects nearly 5% of patients undergoing endovascular thrombectomy for acute ischemic stroke. This study developed a risk score to identify patients at high risk for CA-AKI and associated poor outcomes.
Area of Science:
- Nephrology
- Neurology
- Cardiovascular Medicine
Background:
- Contrast-associated acute kidney injury (CA-AKI) is a known complication of iodinated contrast media.
- Its incidence and impact in endovascular thrombectomy (EVT) for acute ischemic stroke (AIS) are not well-defined.
- No validated prediction tool currently exists for CA-AKI in this patient population.
Purpose of the Study:
- To determine the incidence and prognostic significance of CA-AKI in EVT-treated AIS patients.
- To develop and validate a predictive score for CA-AKI in this cohort.
Main Methods:
- A retrospective, international, multicenter cohort study of 6,638 EVT-treated AIS patients.
- CA-AKI defined by KDIGO criteria (creatinine increase ≥0.3 mg/dL or ≥1.5 times baseline within 48 hours).
- Development and validation of a preprocedural risk score using routine clinical variables.
Main Results:
- CA-AKI occurred in 4.9% of patients and was independently linked to increased in-hospital mortality and poor 90-day functional outcomes (mRS >3).
- A preprocedural risk model demonstrated acceptable discrimination (AUC 0.710) and calibration.
- Models including EVT-related variables showed similar performance.
Conclusions:
- CA-AKI is an independent predictor of adverse outcomes in EVT-treated AIS patients.
- A simple preprocedural risk score can identify high-risk individuals.
- This score may aid in implementing preventive strategies for CA-AKI.
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