[Acute renal failure in the course of renal-ocular syndrome]

Acute tubulointerstitial nephritis with uveitis is described as TINU syndrome. This syndrome, known as a renal-ocular disease, is a rare problem. Until now there have been described 200 cases of TINU all over the world. The most frequent morbidity concerns girls and young women although it may occur at any age. Etiology of this syndrom is unknown. Diagnosis is often difficult as in approximately 65% of cases, ocular symptoms occur later than tubulointerstitial nephritis. General symptoms (fever, weight loss, weakening, fatigue) are frequently nonspecific. There are no randomized studies dealing with treatment of TINU syndrome. Glucocoticosteroids and immunosuppressive drugs are mainly administered. The prospects are generally good, particularly among young children. However, in some patients chronic renal failure develops. Uveitis is treated locally with steroids. The prospects are good as well but inflammation process returns. A study of TINU syndrome has a general purpose of reminding of this disease which is often forgotten by doctors and the problems connected with diagnostics and treatment.