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TGR5 in inflammation and cardiovascular disease
1*Room K1-112, Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Biochemical Society Transactions
|March 21, 2014
Summary
Takeda G-protein-coupled receptor 5 (TGR5) regulates energy expenditure and bile acid signaling. Emerging evidence highlights TGR5
Area of Science:
- Immunology and Pharmacology
- G-protein-coupled receptor signaling
Background:
- Takeda G-protein-coupled receptor 5 (TGR5), also known as GPBAR1, is identified as a bile acid receptor.
- TGR5 plays roles in energy expenditure, GLP-1 secretion, and gallbladder filling.
- Growing evidence indicates TGR5 involvement in inflammatory processes.
Purpose of the Study:
- To review the current understanding of TGR5.
- To focus on TGR5's potential as a therapeutic target for inflammation-driven diseases.
Main Methods:
- Literature review of existing studies on TGR5.
- Analysis of TGR5's role in inflammatory pathways, particularly macrophage NF-κB activity.
- Examination of animal studies investigating TGR5 in disease models.
Main Results:
- TGR5 signaling inhibits inflammatory responses in macrophages by interfering with NF-κB activity.
- Animal studies suggest TGR5 is a potential therapeutic target for atherosclerosis and other inflammation-driven diseases.
Conclusions:
- TGR5 is a significant mediator in inflammatory processes.
- Targeting TGR5 offers a promising strategy for treating inflammatory diseases such as atherosclerosis.
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