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Limited acute influences of electrical baroreceptor activation on insulin sensitivity and glucose delivery: a

Marcus May1, Jelka Ahrens1, Jan Menne2

  • 1Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany.

Diabetes
|March 21, 2014
PubMed

Insights

Electrical carotid sinus stimulation did not affect insulin sensitivity or muscle glucose delivery in hypertensive patients. Baroreflex manipulation showed limited acute impact on muscle glucose metabolism.

Area of Science:

  • Cardiovascular Physiology
  • Metabolic Regulation
  • Hypertension Research

Background:

  • Arterial baroreflexes influence sympathetic nervous system activity, potentially regulating skeletal muscle glucose delivery.
  • Understanding baroreflex modulation of glucose metabolism is crucial for managing metabolic disorders in hypertension.

Purpose of the Study:

  • To investigate if electrical carotid sinus stimulation, a method to manipulate baroreflex activity, impacts insulin sensitivity.
  • To determine if baroreflex manipulation alters muscular glucose delivery in hypertensive patients.

Main Methods:

  • A randomized, double-blind, crossover study involving 16 hypertensive patients using an electrical carotid sinus stimulator.
  • Frequently sampled intravenous glucose tolerance tests (FSIGT) were performed with and without stimulation.
  • Microdialysis monitored interstitial glucose, lactate, and pyruvate in the vastus lateralis muscle.

Main Results:

  • No significant differences in arterial glucose or insulin levels were observed between stimulation conditions.
  • Whole-body insulin sensitivity remained unchanged (P = 0.7) with the stimulator on versus off.
  • Interstitial muscle glucose, lactate, and pyruvate concentrations increased similarly during FSIGT regardless of stimulation.

Conclusions:

  • Acute baroreceptor stimulation via carotid sinus stimulation does not significantly alter whole-body insulin sensitivity.
  • Baroreflex-mediated sympathetic vasomotor tone has a limited acute effect on muscle glucose metabolism in hypertensive individuals.

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