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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
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Infants 1-90 days old hospitalized with human rhinovirus infection

Jeffrey M Bender1, Charla S Taylor, Joven Cumpio

  • 1Department of Pediatrics, Kaiser Permanente, Los Angeles Medical Center, Los Angeles, California; Division of Pediatric Infectious Diseases, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, California.

Journal of Clinical Laboratory Analysis
|March 21, 2014
PubMed

Insights

Human rhinovirus (HRV) infections in hospitalized infants led to longer hospital stays than respiratory syncytial virus (RSV) infections. Further research is needed to understand HRV

Area of Science:

  • Pediatric Infectious Diseases
  • Viral Respiratory Illnesses
  • Neonatal Health

Background:

  • Human rhinovirus (HRV) is a frequent cause of respiratory illness in children.
  • The specific impact of HRV infection on infants aged 1-90 days remains unclear.
  • This study hypothesized that HRV infection would present clinically similarly to respiratory syncytial virus (RSV) in hospitalized infants.

Purpose of the Study:

  • To compare the clinical presentation and outcomes of hospitalized infants with HRV infection versus RSV infection.
  • To investigate the impact of HRV on neonatal respiratory illness.

Main Methods:

  • A retrospective study was conducted on hospitalized infants (1-90 days old) diagnosed with HRV or RSV.
  • Data were collected from the Southern California Kaiser Permanente network over a one-year period (August 2010 to October 2011).
  • Respiratory virus testing was performed on 245 infants.

Main Results:

  • HRV was detected in 21% of infants, while RSV was found in 32%.
  • Infants with HRV experienced significantly longer hospital stays (median 4 days) compared to those with RSV (median 3 days).
  • HRV-infected infants had fewer short hospital stays (≤3 days) and a trend towards younger age and increased fever.

Conclusions:

  • HRV infection in hospitalized infants is associated with longer hospital stays compared to RSV.
  • Advances in diagnostics aid in identifying diverse viral pathogens in infants.
  • Further research and improved diagnostic methods are necessary to fully elucidate the effects of HRV in young infants.
Abstract

Keywords:
febrile infantrespiratory syncytial virusrespiratory virusesserious bacterial infection

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