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Bone morphogenetic protein-2 antagonizes bone morphogenetic protein-4 induced cardiomyocyte hypertrophy and apoptosis

Jing Lu1, Bo Sun, Rong Huo

  • 1Department of Pharmacology (The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), Harbin Medical University, Harbin, 150086, P.R. China.

Journal of Cellular Physiology
|March 21, 2014
PubMed

Insights

Bone morphogenetic protein-2 (BMP2) counteracts BMP4-induced heart cell damage and death. BMP2 activates Akt and inhibits JNK pathways, offering protective effects against cardiac hypertrophy and apoptosis.

Area of Science:

  • Cardiovascular Biology
  • Molecular Cardiology
  • Cell Signaling

Background:

  • Bone morphogenetic protein-4 (BMP4) up-regulation is linked to pathological cardiac hypertrophy.
  • BMP4 promotes cardiomyocyte hypertrophy and apoptosis.
  • Bone morphogenetic protein-2 (BMP2) and BMP4 share significant homology and interact.

Purpose of the Study:

  • To investigate BMP2 expression changes in cardiac hypertrophy models.
  • To determine the effects of BMP2 on BMP4-induced cardiomyocyte hypertrophy and apoptosis.

Main Methods:

  • In vivo cardiac hypertrophy models induced by pressure-overload and swimming exercise in mice.
  • Analysis of BMP2 mRNA and protein expression.
  • Assessment of BMP2's effects on cardiomyocyte hypertrophy and apoptosis, both independently and in conjunction with BMP4.
  • Investigation of signaling pathways involving Akt and JNK.

Main Results:

  • BMP2 expression was elevated in pressure-overload and swimming-exercise induced cardiac hypertrophy.
  • BMP2 alone did not induce cardiomyocyte hypertrophy or apoptosis.
  • BMP2 antagonized BMP4-induced cardiomyocyte hypertrophy and apoptosis.
  • BMP2 activated Akt and inhibited JNK activation in cardiomyocytes, mediating its protective effects.

Conclusions:

  • BMP2 antagonizes BMP4-induced cardiomyocyte hypertrophy and apoptosis.
  • The anti-apoptotic actions of BMP2 against BMP4 involve Akt activation and JNK inhibition.

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