Related Experiment Video
Updated: May 2, 2026
06:58
Non-restraining EEG Radiotelemetry: Epidural and Deep Intracerebral Stereotaxic EEG Electrode Placement
Published on: June 25, 2016
19.0K
Cefepime- Induced Non-Convulsive Status Epilepticus (NCSE).
Ahro Kim1, Ji-Eun Kim1, Young-Min Paek1
1Department of Neurology, Ilsan Paik Hospital, Inje University College of Medicine.
Journal of Epilepsy Research
|March 21, 2014
Summary
Cefepime, a common antibiotic, can cause neurotoxicity like nonconvulsive status epilepticus (NCSE) in patients, especially those with kidney issues. This case highlights the importance of monitoring for antibiotic-induced NCSE in critically ill patients.
Area of Science:
- Neurology
- Pharmacology
- Critical Care Medicine
Background:
- Cefepime, a fourth-generation cephalosporin, is frequently used in immunosuppressed patients.
- Neurotoxicity, including nonconvulsive status epilepticus (NCSE), is a known but infrequent adverse effect of cefepime, particularly in patients with renal impairment.
Observation:
- A 71-year-old woman developed stupor and myoclonic seizures after cefepime treatment for atypical pneumonia, following recovery from acute renal failure managed with continuous renal replacement therapy (CRRT).
- Electroencephalography (EEG) confirmed nonconvulsive status epilepticus (NCSE).
Findings:
- The patient's neurological symptoms resolved within 3 days of discontinuing cefepime.
- The diagnosis was cefepime-induced nonconvulsive status epilepticus (NCSE).
Implications:
- This case underscores the importance of recognizing cefepime-induced neurotoxicity, specifically NCSE, in critically ill patients, even after renal function has improved.
- Vigilance for potential antibiotic-induced neurological complications is crucial for timely diagnosis and management, leading to reversible outcomes.
More Related Videos
09:06Manipulation of Epileptiform Electrocorticograms ECoGs and Sleep in Rats and Mice by Acupuncture
Published on: December 22, 2016
9.2K
08:28Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus
Published on: April 5, 2011
17.1K
Related Concept Videos
01:20Seizures l: Introduction
42
Understanding seizures and epilepsy relies on key definitions that help in recognizing, classifying, and managing these disorders. These definitions provide a framework for recognizing, classifying, and managing seizure disorders.DefinitionsA seizure is a sudden, abnormal burst of electrical activity in the brain that can cause changes in awareness, movement, sensation, or behavior, depending on the area involved. Epilepsy is a chronic condition characterized by recurrent, unprovoked seizures,...
42
01:13Seizures: Classification
2.5K
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
2.5K
01:24Epilepsy and Seizures: Overview
1.7K
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.7K
01:22Epilepsy ll: Types
47
Recurrent seizures, stemming from abnormal electrical activity in the brain, are the defining characteristic of epilepsy, a chronic neurological condition. Because seizure features vary greatly, epilepsy is classified using two systems: by seizure type and by epilepsy syndromes. These classifications enable clinicians to describe seizure patterns and select suitable treatment strategies.I. Classification by Seizure Type1. Focal EpilepsyFocal epilepsy begins in one hemisphere of the brain.
47
01:19Seizures ll: Types
36
Seizures are sudden bursts of abnormal electrical discharge in the brain that interfere with normal function. They are commonly divided into three groups: focal seizures, generalized seizures, and other types that do not fit neatly into either category.Focal SeizuresFocal seizures begin in a single brain region. When awareness is preserved, they are called focal aware seizures and may cause sensations such as tingling, unusual smells, or flashing lights. When awareness is impaired, they are...
36
01:20Antiepileptic Drugs: Potassium Channel Activators
1.0K
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
Ezogabine has gained approval as an adjunctive treatment...
1.0K