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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Renewal of Skin Epidermal Stem Cells

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...

Cells of the Epidermis

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...

Cellular Adaptation IV: Dysplasia and Metaplasia

Cellular Adaptation IV: Dysplasia and Metaplasia

DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...

Basal Lamina are the Specialized Form of ECM

Basal Lamina are the Specialized Form of ECM

The basal lamina is a thin extracellular layer that lies underneath the cells and separates them from other tissues. The three layers of the basal lamina are lamina lucida, lamina densa and lamina reticularis. The basal lamina, a mixture of glycoproteins and collagen, provides an attachment site for the epithelium, separating it from underlying connective tissue. The framework of basal lamina has other essential proteins such as laminins mesh, perlecan, entactin, and type IV collagen.
Proteins...

Layers of the Epidermis

Layers of the Epidermis

The epidermis, the outermost layer of the skin, is composed of several distinct layers. From deep to superficial, the layers of the epidermis are as follows:
Stratum Basale
Stratum basale, also known as the stratum germinativum, is the deepest layer of the epidermis. It is composed of a single layer of actively dividing cells called basal cells or basal keratinocytes. These cells constantly undergo cell division to replenish the upper layers of the epidermis. Additionally, melanocytes, which...

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Updated: May 2, 2026

Cell Population Analyses During Skin Carcinogenesis

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

[Basal cell carcinomas].

Catherine Renaud-Vilmer, Nicole Basset-Seguin

La Revue Du Praticien

|March 22, 2014

Summary

This summary is machine-generated.

Basal cell carcinomas (BCC), the most common skin cancer, are primarily caused by sun exposure. Treatment involves surgical excision, with new options emerging for this heterogeneous condition.

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Area of Science:

Dermatology
Oncology

Context:

Basal cell carcinomas (BCC) are the most prevalent form of skin cancer, accounting for 80% of non-melanoma skin cancers.
Excessive sun exposure is the primary risk factor, leading to BCCs commonly appearing on sun-exposed areas like the head and neck.

Purpose:

To provide an overview of basal cell carcinomas, including their epidemiology, risk factors, and standard treatment.
To highlight the heterogeneity of BCC presentations and the evolving therapeutic landscape.

Summary:

BCCs are the most common cancers, linked to sun exposure and often located on the head and neck, necessitating consideration of aesthetic and functional outcomes.
Standard treatment involves surgical excision with clear margins, typically an outpatient procedure. Diverse clinicopathologic forms present challenges, driving the development of new therapeutic options.
Prevention strategies emphasize sun protection and early detection in high-risk individuals with lighter phototypes.

Impact:

Informs clinicians and patients about BCCs, emphasizing prevention and the importance of considering cosmetic and functional outcomes in treatment planning.
Highlights the need for tailored treatment approaches due to the varied nature of BCCs and the emergence of novel therapies.
Underscores the significance of sun protection and early lesion detection for managing this widespread malignancy.