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Updated: May 2, 2026
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Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential
Published on: July 21, 2023
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Are asthmatic patients prone to bone loss?
Jae-Woo Jung1, Hye-Ryun Kang2, Ju-Young Kim2
1Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea; Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
Summary
Airway hyperresponsiveness (AHR) and asthma are linked to decreased bone mineral density (BMD), increasing the risk of osteopenia and osteoporosis. Further research is needed to clarify the causal relationship between these conditions.
Area of Science:
- Pulmonary Medicine
- Endocrinology
- Bone Health
Background:
- Emerging evidence suggests a link between allergic diseases like asthma and reduced vitamin D levels, a known osteoporosis risk factor.
- The relationship between asthma and bone loss remains unclear, necessitating further investigation.
Purpose of the Study:
- To determine if airway hyperresponsiveness (AHR) or asthma diagnosis correlates with significant changes in bone mineral density (BMD).
Main Methods:
- Retrospective analysis of 7,034 patients undergoing health checkups, including BMD tests and methacholine bronchial challenge tests.
- Asthma was identified via physician diagnosis; patients with prior systemic corticosteroid use were excluded.
Main Results:
- Patients with AHR exhibited significantly lower lumbar spine and femur BMD compared to those without AHR.
- AHR and asthma were associated with a higher prevalence of osteopenia or osteoporosis, even after adjusting for confounding factors.
Conclusions:
- Airway hyperresponsiveness and asthma are associated with clinically significant reductions in bone mineral density.
- The causal link between AHR, asthma, and bone loss requires further elucidation.
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