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Related Concept Videos

Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

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Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory...
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Diabetic Neuropathy01:22

Diabetic Neuropathy

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DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
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Diabetic Retinopathy01:27

Diabetic Retinopathy

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DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
55
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

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The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
1.5K
Diabetic Nephropathy01:28

Diabetic Nephropathy

32
Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration...
32
Complications of Diabetes Mellitus01:22

Complications of Diabetes Mellitus

35
Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...
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Related Experiment Video

Updated: May 2, 2026

Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds
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Combination therapy accelerates diabetic wound closure.

Robert J Allen1, Marc A Soares1, Ilyse D Haberman1

  • 1Institute of Reconstructive Plastic Surgery, New York University Langone Medical Center, New York, New York, United States of America.

Plos One
|March 22, 2014
PubMed
Summary
This summary is machine-generated.

Diabetic foot ulcers impair healing due to poor neovascularization. Combination therapy with AMD3100 and PDGF-BB improves progenitor cell mobilization and trafficking, accelerating wound closure by 40%.

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Protocol to Create Chronic Wounds in Diabetic Mice
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Area of Science:

  • Regenerative Medicine
  • Diabetic Complications
  • Wound Healing Research

Background:

  • Diabetic foot ulcers lead to amputation and hospitalization.
  • Impaired neovascularization and progenitor cell (PC) mobilization cause poor diabetic wound healing.
  • No current FDA-approved therapies address this PC defect.

Purpose of the Study:

  • To investigate a novel combination therapy using AMD3100 and PDGF-BB to enhance diabetic wound healing.
  • To assess the efficacy of this endogenous progenitor cell strategy in improving neovascularization and wound closure.

Main Methods:

  • A preclinical model of type II diabetic wound healing was used.
  • Mice were treated with saline, AMD3100, PDGF-BB, or a combination therapy.
  • Circulating progenitor cell numbers and wound vascularity were analyzed.

Main Results:

  • AMD3100 alone improved PC mobilization but not neovascularization in diabetic mice.
  • PDGF-BB rescued a trafficking defect in AMD3100-treated diabetic PCs.
  • Combination therapy restored diabetic wound neovascularization and accelerated closure by 40%.

Conclusions:

  • Combination AMD3100 and PDGF-BB therapy synergistically enhances bone marrow progenitor cell mobilization and trafficking.
  • This strategy significantly improves diabetic wound closure and neovascularization.
  • The use of FDA-approved therapies makes this approach highly translatable for diabetic wound healing.