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Interferon (IFN)-like antiviral effect is induced by unspecific cross-linking of cell surface receptors
G Premecz1, A Markovits, G Bagi
1Microbiological Research Group, National Institute of Hygiene, Budapest, Hungary.
FEBS Letters
|January 30, 1989
Abstract:
Treatment of human amniotic cells (UAC) with Cytodex 1 (DEAE-dextran) results in the development of an antiviral state of the cells, as proven by studying (i) the cytopathic effect and (ii) [3H]uridine incorporation into the RNA of vesicular stomatitis virus (VSV) after VSV infection. The same treatment transiently triggers the breakdown of inositol phospholipids and activates the translocation of protein kinase C (PKC). On the basis of these data it can be suggested that cross-linking of cell surface receptors by a solid carrier bearing covalently bound positive charges may result in IFN-like effects.