Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

2.1K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
2.1K
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

28
Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
28
Liver Physiology01:30

Liver Physiology

3.8K
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
3.8K
Overview of Fatty Acid Metabolism01:28

Overview of Fatty Acid Metabolism

25.4K
Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
25.4K
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

906
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
906
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

26
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80%...
26

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cortical Thickness and Appetite Hormones in Adolescent Obesity and Binge Eating Disorder: A Comparative Study.

The International journal of eating disorders·2026
Same author

Neuropsychiatric Features, ADHD and Cognitive Disengagement Syndrome in Children and Adolescents With Celiac Disease: A Controlled Study.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience·2026
Same author

Clinical, Endoscopic, and Pathologic Spectrum of Pediatric Polyps: A Single-Center Study in the Current Polypectomy Era.

Journal of clinical medicine·2026
Same author

Hepatic Histopathological Benefit, Microbial Cost: Oral Vancomycin Mitigates Non-Alcoholic Fatty Liver Disease While Disrupting the Cecal Microbiota.

International journal of molecular sciences·2025
Same author

Integrating PEESS, EREFS, and endoscopic ultrasonography in the multimodal management of pediatric eosinophilic esophagitis: A 4-year retrospective institutional experience.

Medicine·2025
Same author

Anesthetic planning and management for successful separation surgery of pygopagus conjoined twins: a multidisciplinary approach.

Journal of surgical case reports·2025

Related Experiment Video

Updated: May 2, 2026

Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis
06:26

Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis

Published on: July 18, 2025

1.2K

Fatty liver in childhood.

Yesim Ozturk1, Ozlem Bekem Soylu1

  • 1Yesim Ozturk, Department of Pediatrics, Division of Pediatric Gastroenterology, Dokuz Eylul University School of Medicine, Inciralti, 35340 İzmir, Turkey.

World Journal of Hepatology
|March 22, 2014
PubMed
Summary

Fatty liver disease is a growing global health issue, particularly in children, linked to obesity and insulin resistance. Current management focuses on lifestyle changes like diet and exercise, as effective treatments are still developing.

Keywords:
ChildrenChronic liver diseaseInsulin resistanceMetabolic syndromeNonalcoholic fatty liver diseaseNonalcoholic steatohepatitisObesity

More Related Videos

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
07:03

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Published on: July 19, 2024

1.9K
Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
08:41

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Published on: March 24, 2023

2.1K

Related Experiment Videos

Last Updated: May 2, 2026

Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis
06:26

Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis

Published on: July 18, 2025

1.2K
Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
07:03

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Published on: July 19, 2024

1.9K
Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
08:41

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Published on: March 24, 2023

2.1K

Area of Science:

  • Hepatology
  • Pediatric Gastroenterology
  • Public Health

Background:

  • Fatty liver disease is a significant and increasing global health concern.
  • It can progress to severe conditions like nonalcoholic steatohepatitis, cirrhosis, and hepatocellular carcinoma.
  • Prevalence is rising due to changes in diet, lifestyle, and increased rates of childhood obesity and insulin resistance.

Purpose of the Study:

  • To review the current understanding of fatty liver disease in children.
  • To highlight key risk factors and the importance of early consideration in obese children.
  • To discuss current management strategies and the limitations of available treatments.

Main Methods:

  • Literature review of fatty liver disease, focusing on pediatric populations.
  • Analysis of risk factors including obesity, insulin resistance, genetics, and ethnicity.
  • Evaluation of current and emerging treatment and management approaches.

Main Results:

  • Nonalcoholic fatty liver disease (NAFLD) is increasingly diagnosed in children, often asymptomatic.
  • Obesity and insulin resistance are primary risk factors, though other factors also contribute.
  • While cirrhosis in children is rare, NAFLD should be suspected in obese pediatric cases.

Conclusions:

  • NAFLD lacks a definitive cure, with weight loss through family-based lifestyle interventions being the primary management.
  • Recommended interventions include exercise and a diet low in glycemic index with appropriate calorie control.
  • Pharmacological treatments show promise but are not yet sufficient for widespread use in children.